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Splitting the dose, as mentioned earlier (e.g., 250 mcg in the morning and 250 mcg at night), is a strategy we frequently see
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Hypothalamic dysfunction is related to sleep impairment and CSF biomarkers in Alzheimer's disease
In agreement with this hypothesis, thiol groups from specific proteins [tyrosine phosphatase (Sumi, 2008) and creatine kinase (Wang et al., 2001)] are more nucleophilic and, consequently, more reactive than GSH (Farina et al., 2010)
