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Magnesium plays a role in over 300 enzymatic reactions including muscle function, nerve transmission, blood sugar regulation, and the synthesis of serotonin and GABA
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[115] This functionality is lost in vitamin B 12 deficiency, resulting in an increased homocysteine level and the trapping of folate as 5-methyl-tetrahydrofolate, from which THF (the active form of folate) cannot be recovered
