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Description
Inhibiting TRPA1 ion channel reduces loss of cutaneous nerve fiber function in diabetic animals: sustained activation of the TRPA1 channel contributes to the pathogenesis of peripheral diabetic neuropathy

This is specifically true if you already struggle with low B12, iron deficiency, fatigue, or nausea
Plant J 57(1):160170 Ding D, Zhang L, Wang H, Liu Z, Zhang Z, Zheng Y (2009) Differential expression of miRNAs in response to salt stress in maize roots

Metformin can also affect epigenome and gene expression to influence aging
