glutathione for stroke system enhancement cardiac protection: pharmacological options against oxidative stress and ferroptosis Mechanism of ferroptosis in hypertension

The development of quantitative AOP Networks is a logical next step, but this presents a formidable challenge in complexity

Documentation of iron deficiency without hematologic evidence of such (hypochromasia in blood smears, low MCV, low MCHC) is difficult because serum iron concentrations are not the best surrogate of iron stores and ferritin, the iron storage protein, can be increased by inflammation

In addition, bivalent inhibitors of GSTs are able to bind to both active sites and interact with both junction and cleft regions of the enzyme, thus showing even higher affinity and better isozyme selectivity compared to monovalent inhibitors [203]

10.1016/j.abb.2007.05.001 Arch