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In addition to promoting mitochondrial biogenesis, creatine appears to influence mitochondrial dynamics by modulating the balance between fission and fusion processes [27], which are essential for mitochondrial quality control, adaptation to energetic stress, and inter-organelle communication

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Figure 10 5.4 Protective effects on pulmonary disease via multifaceted mechanisms Respiratory infectious diseases remain a significant global challenge, as demonstrated by the COVID-19 pandemic, which was caused by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) and annual influenza outbreaks (114)