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Inadequate process validation and weak CAPA effectiveness checks FDA findings Process validation remains a recurring weakness

This transfer of electrons along the electron transport chain is coupled with the transport of protons across the inner membrane, establishing the electrochemical gradient that generated ATP [42]

These results are consistent with the findings of Schilperoort and colleagues, who reported that circadian disruption can result in altered trabecular bone structure and reduced levels of bone resorption markers (serum tartrateresistant acidic phosphatases) and bone formation markers (serum PINP) in mice [136]