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It also appears that the development of cholestatic DILI with one statin does not preclude the use of other statins without liver injury recurrence

Decreased activity of complexes I and II is closely associated with reduced ATP production in cardiomyocytes of male obese rats with IR (117), and the inhibition of cytochrome c oxidase and complex IV deteriorates dysfunctional mitochondria and decreases ATP levels (118)

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Subsequently, H 2 O 2 is further transformed into the highly reactive OH via the Fenton reaction, which requires the presence of reduced iron or copper ions (Halliwell and Gutteridge 1990)
