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In addition, de novo sphingolipid biosynthesis is essential for autophagy induction in macrophages, which plays a protective role by clearing excess lipids from LDs through the turnover of ORMDL sphingolipid biosynthesis regulator 1 (ORMDL1) protein, a negative regulator of serine palmitoyl-CoA transferase activity (Wang et al., 2015b)

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Though the discovery of ferroptosis at the beginning of this century sparked much research and discussion, the application of ferroptosis in treating IS is still a lengthy process

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found no significant difference in total ferritin between ALS and control groups (340)

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Synaptic Maintenence The synaptic repair therapeutic strategy takes advantage of the dynamic nature of synaptic structure and function, which is the regenerative ability and reversibility of malfunction, and encompasses three main synaptic aspects: transmission, growth, and plasticity [126]

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