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This may be related in part to dose-related preferential recruitment of receptor subtype, since the adenosine A 1 receptor exhibits many opposing physiological functions to those mediated by the A 2A receptor, including stimulation of neutrophil adherence to endothelial cells
[5] It is also the most abundant excitatory neurotransmitter in the vertebrate nervous system

(PubMed) Quinn JF, Raman R, Thomas RG, et al

Overall, colorectal cancer ranks in third place in terms of incidence, and second in terms of mortality, representing about 10% of the cancer cases and deaths worldwide [75]
