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Furthermore, with respect to dopaminergic signaling, a reduction in anxiety-like behaviors and an increase in locomotor activity in 3xTg mice are accompanied by an increase in postsynaptic D2 dopamine receptors in the striatum and in D2-autoreceptors in substantia nigra/VTA cell bodies (Gloria et al., 2021)

Depending on the cellular redox milieu and cell type, Fos and Jun can dimerize or interact with other transcription factors such as ATF, C/EBP and Maf leading to activation or inhibition of gene transcription of antioxidant and immunoactive proteins (169, 360)

Bellmund, J

However, it did not reduce pain, burning, or numbness based on two other symptom scales [7][27]
