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On the other hand, another study found that 3-month treatment with NR in a PD mouse model resulted in increased NMN and NAD + metabolism marker NAAD but did not increase NAD + levels 287
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This maintenance phase begins only after the initial deficiency has been corrected and the patients blood markers have stabilized within the normal range

Managing this condition requires lifelong B12 supplementation (usually via injection) and regular veterinary monitoring
