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Category C is where much of the clinical complexity lives symptomatic, hemodynamically stable patients subdivided into C1, C2, and C3 based on RV function and biomarkers
a ligand having low affinity can be useful for targeting the microvascular endothelium
Bax, when released from Bcl-2, will induce a mitochondrial permeability transition (MPT) in response to this oxidative stress [238], which will trigger cytochrome c to be released from mitochondria, activating caspase-mediated apoptosis [235]
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