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Pathogenetic changes in this disease include anatomical and functional complexes

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This article begins with an overview of basic pathological mechanisms and offers a comprehensive overview of relevant therapeutic approaches and future development directions, aiming to facilitate the transition of the field from traditional generalized therapies to personalized precision medicine and to bridge the long-standing gap between basic research and clinical practice.

One of the most critical yet overlooked biochemical pathways is methylation, a process that affects detoxification, DNA repair, immune function, neurotransmitter balance, fertility and cardiovascular health. Central to the methylation process is the MTHFR (methylenetetrahydrofolate reductase) enzyme, which plays a []