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S-glutathionylation reactions, mediated by Grx2, play a central role in regulating mitochondrial ATP production and ROS emission in response to local and robust changes in redox environment, in particular fluctuations in H 2 O 2 and 2GSH/GSSG

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Further evaluation of autophagy flux was conducted through HaloTag processing assays (Yim et al, 2022), which utilize the resistance of ligand-bound Halo to lysosomal degradation