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Pulmonary neuroendocrine cells function as airway sensors to control lung immune response

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85 Moreover, the systems pharmacology approaches integrating the biology of anti-VEGF resistance with the prognostic, predictive, pharmacodynamic and surrogate biomarkers coupled with computational imaging techniques such as dynamic contrast-enhanced magnetic resonance imaging and other imaging tools monitoring the vessel permeability, integrity and tumor perfusion might be helpful in ameliorating the drug resistance and optimizing the performance of anti-angiogenic drugs 86

Experimental data also propose that Epithalon may modulate histone-DNA interactions, potentially altering chromatin accessibility and influencing transcription processes