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Specifically, these Tfam-ENSKO (ENS knockout) mice exhibited premature death beginning at 60 days old due to chronic intestinal pseudo-obstruction (CIPO)

Venturelli S., Burkard M., Biendl M., et al., Prenylated Chalcones and Flavonoids for the Prevention and Treatment of Cancer, Nutrition (Burbank, Los Angeles County, Calif) 32, no

It has been administered orally, intraperitoneally, subcutaneously, topically, and intravenously in doses that range from 10ng/kg to 50g/kg

Annu Rev Nutr (1990) 10:41531.10.1146/annurev.nu.10.070190.002215 117 AkilMBrewerGJ
