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Genetic variants in several B6-related genes can increase your need for vitamin B6

doi: 10.1371/journal.pone.0025298 94 EdwardsJ

Protein not absorbed in the small intestine undergoes microbial fermentation in the colon, producing branched-chain fatty acids (BCFAs), ammonia, hydrogen sulfide, and phenolic compounds

Leptin therapy reverses hyperglycemia in mice with streptozotocin-induced diabetes, independent of hepatic leptin signaling
