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7.1.1 Use of cytokine inhibitors Cytokines, particularly pro-inflammatory cytokines such as tumor necrosis factor-alpha (TNF- ), interleukin (IL)-1, and IL-6, are known to contribute significantly to BBB dysfunction and neuroinflammation following I/R injury (Jurcau and Simion, 2021)

In our review, some ( Patients with vitamin B12 deficiency who are symptomatic have severe neurological deficits or have critically low blood levels of vitamin B12 should be treated with IM administration

doi: 10.1007/s12602-017-9322-6 152 BurgueoJFAbreuMT

In CMT4B3 fibroblasts, Myo-Ins did not improve any respiratory parameter, consistent with the requirement for intact mitochondrial function and PIP signalling to support Myo-Insmediated enhancement of mitochondrial plasticity