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Some of the left lungs were fixed in 4% paraformaldehyde for HE and MT staining

In diabetic kidneys (51), hyperglycemia and AGEs prompt renal tubular cells to excessively express chemokines and adhesion molecules, thereby facilitating the recruitment of monocytes and the infiltration of macrophages into the glomeruli and interstitium

2 Factors that further increase risk of hepatotoxicity include HBV/HCV co-infection, alcoholism, substance abuse, abnormal baseline liver function

The gut microbiota plays an undeniable role in the metabolism of UA in the intestines, which could involved in the metabolism of purines and uric acid and degrade UA into Short-chain fatty acid (SCFAs) such as acetic acid and butyric acid (14, 15)