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Generally, Cu2+ is converted to Cu+ by reductase enzymes such as duodenal cytochrome b (DCYTB) and six-layer epithelial antigen (Fig

So far, several types of tumors have been classified into reactive oxygen species (ROS)-driven tumors and include EBV-associated Burkitts lymphoma, Hodgkins disease, gastric carcinoma, hepatitis C virus-related hepatocellular carcinoma, ultraviolet A-induced melanoma, inflammatory bowel disease-induced colon carcinoma, schistosomiasis-induced bladder cancer, tobacco-induced oral and lung carcinoma, and epidermolysis bullosa-associated squamous cell carcinoma

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Among these cells, MSCs represent a particularly attractive option and have been widely used in regenerative medicine owing to their easy preparation, self-renewal ability, multilineage differentiation potential, and anti-inflammatory and immunosuppressive properties 8