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Dans le contexte de la source Guilland 2013, il parait s'agir des adultes atteints de manifestations cliniques (maladie de Biermer) par rapport la population gnrale dans les pays dvelopps

Finally, THAP11 deficiency (Quintana et al., 2017) and ZNF143 deficiency (Pupavac et al., 2016) also affect the transcriptional regulation of MMACHC
While individual results vary, many patients experience: Noticeable weight loss within the first month Reduced appetite and fewer cravings Steady, sustainable fat loss (not just water weight) Increased energy and motivation Patients often report better sleep, more consistent moods, and improved confidencebecause when your body starts feeling better, everything else improves too

Genetic factors may also play a role
