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Abstract Providing NO-system importance, we suggest that one single application of the NOS-blocker L-NAME may induce retinal ischemia in rats, and that the stable pentadecapeptide BPC 157 may be the therapy, since it may interact with the NO-system and may counteract various adverse effects of L-NAME application

Genome Med , 2012, 4(8): 67-77

473 Mixed lineage kinase 3, a member of the MAP3K family, regulates the JNK/p53 pathway to mediate SLC7A11 expression and oxidative stress, causing myocardial fibrosis in the late stage of chronic heart failure in the TAC mouse model

It allows the body to readjust without putting it through the stress of withdrawal symptoms