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compared twice-daily oral administrations of 75 mg pregabalin alone ( n = 15) to an arm additionally treated with oral doses of 100 mg alpha lipoic acid (ALA) and 750 g methylcobalamin ( n = 15) over a period of 12 weeks

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The study found that NNMT inhibitors "reduced intracellular 1-MNA, increased intracellular NAD+ and S-(5-adenosyl)-L-methionine (SAM), and suppressed lipogenesis." This metabolic improvement occurs within days of starting treatment, before any weight loss becomes measurable

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