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Chronic oral toxicology studies in Han Wistar rats (6 months) and cynomolgus monkeys (9 months) found no treatment-related unscheduled deaths, toxicologically significant clinical signs, or adverse changes in organ masses, electrocardiographic parameters, or histological profiles at the concentrations examined

Suggested Reading: Causes and Treatment of Decreased Libido in Women Diet Vitamin B12 is primarily found in animal products, so individuals following a vegetarian or vegan diet may be at risk of vitamin B12 deficiency if they do not consume fortified foods or supplements

doi: 10.1016/j.nut.2009.03.012

Placental transport and fetal utilization of leucine in a model of fetal growth retardation