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Following weighting and blood sampling, standard light breakfasts were provided

Arora R, Nimonkar AV, Baird D, Wang C, Chiu CH, Horton PA, Hanrahan S, Cubbon R, Weldon S, Tschantz WR, Mueller S, Brunner R, Lehr P, Meier P, Ottl J, Voznesensky A, Pandey P, Smith TM, Stojanovic A, Flyer A, Benson TE, Romanowski MJ, Trauger JW (2019) Structure of lipoprotein lipase in complex with GPIHBP1

Mice bearing hepatic INSR knockout exhibit glucose intolerance, reduced insulin clearance and pronounced hyperinsulinemia [148]

Given the limited reports of bivalent functional effects, further studies may be warranted to investigate the mechanism of bivalent ligands' functional signaling and how they may differ from monovalent ligands