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It's also not mutagenic in cell studies

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Mechanistically, PQS binding increases the histidine methyltransferase (His MTase) activity of CNMT, catalysing methylation of TFR1 at His35

RLS affects women more frequently than men, with parity playing a key role (Trotti, 2017).The problems this study raises would be especially significant in epidemiology studies where non-clinicians conduct telephone surveys with members of the public, with the goal of including only patients with primary RLS (Yeh et al., 2016)