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While all three nitric oxide synthases (NOSs) have been suggested to be potential sources of NO for this reaction4143, current data point toward neuronal NOS (nNOS) as a source

2012 Aug;17(8):799-804

Anti-IGF therapies showed potent anticancer effects and the ability to suppress cancer resistance to various chemotherapy drugs in in vivo and in vitro preclinical studies

What it does WELL: Consistently elevates IGF-1 in randomized controlled trials and restores GH secretion to young-adult levels Increases fat-free mass over weeks and months in two-year double-blind RCT data Improves nitrogen retention and protein balance Enhances REM sleep and total sleep duration an approximately 50% increase in stage IV sleep and 20% increase in REM versus placebo Stimulates appetite via central ghrelin signaling What gets ignored: Consistently worsens insulin sensitivity and raises fasting glucose in multiple human trials a repeatable and replicable finding Commonly causes edema and joint discomfort The ensuing appetite dysregulation often leads to unwanted fat gain (i.e