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Nutritional inadequacies, enzyme defects, and pathological changes to tissues can all contribute to a reduced ability of the body to accomplish the synthesis of the active forms of vitamin B12 from CN-Cbl

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People who are recovering from tendon, ligament, or muscle injuries, with persistent gut disorders (IBD, ulcers, leaky gut), inflammation or tissue damage from NSAIDs, wanting speedier surgery or injury recovery, managing brain-gut dysfunction or systemic inflammation

The intestinal mucosa forms a critical interface between these microbes and the host: a single-cell epithelial layer with tight junctions that limit bacterial translocation, overlain by mucus and patrolled by immune cells [18]