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It appears to be carried out by the participation of all mature liver cell types.43, 44 The process is associated with signaling cascades involving growth factors, cytokines, matrix remodeling, and several feedbacks of stimulation and inhibition of growth related signals.45, 46 The liver manages to restore any lost mass and adjust its size to that of the organism, while at the same time providing full support for body homeostasis during the entire regenerative process

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2 This eventually culminates in respiratory insufficiency and premature death