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These scenarios may represent (a) false negative mutation analysis, (b) wrong diagnosis, or (c) mosaicism and other rare genetic aberrations

Zehethofer et al., 2015), the regulatory effects of FAO and CPT on COPD pathogenesis remains unclear ( CS exposure has been reported to promote FAO and mitochondrial respiration, along with an increased expression of CPT1 in the airway epithelial cells (EpiCs) ( in vitro and in vivo (Shapiro and Ingenito, 2005), which could subsequently promote FAO in EpiC (Schafer et al., 2009)

However, below the threshold, targeted application of mitochondria-related nutraceuticals may reverse the damage and stabilize corresponding conditions