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22,56,57 Cardiovascular diseases and related risk factors (e.g., hypertension, atherosclerosis) impair blood flow to peripheral nerves, worsening neuropathic symptoms

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### Alternative: 2.5mg/mL (Better for Low Doses) | Vial Size | BAC Water to Add | Concentration | Volume per 0.5mg Dose | |-----------|-----------------|---------------|-----------------------| | 5mg | 2.0mL | 2.5mg/mL | 0.20mL | | 10mg | 4.0mL | 2.5mg/mL | 0.20mL | This lower concentration produces larger injection volumes easier to measure precisely, but more volume per shot

Changes from baseline to week 68 in blood pressure (BP) were greater with CagriSema versus placebo (systolic BP: 10.9 versus 2.8 mm Hg