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Mechanistic insights into GLP-1 receptor agonists and reward pathways
This localized depletion of the brain's master antioxidant is accompanied by abnormally high levels of ventricular lactate and free radicals, indicating that the brain is suffering from severe oxidative stress and impaired cellular energy metabolism
Additionally, the inhibitor treatment reduced glutathione and cysteine uptake in MDSCs, indicating that it targets glutathione synthesis from cysteine [53]
