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cells grown on media with sulfur
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In both conformations, the pinane ring of the compound interacts with F324, V469, T471, A481 and L484 in subpocket C (Supplementary Fig
If our hypothesis is confirmed (i.e., some of these host cleavage sites prove to be functional), that leaves us with an interesting questionwhat evolutionary advantages are driving some viruses to go so far as to degrade or block the synthesis of GSH and specific host selenoproteins
