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607 Clausenamide, an alkaloid isolated from Clausena lansium , interacts directly with Ser663 of ALOX5, blocking the nuclear translocation of ALOX5, alleviating lipid peroxide accumulation and ferroptosis in dopaminergic neurons, significantly improving behavioral deficits in PD mouse models, and providing an attractive strategy for PD treatment

[DOI] [PMC free article] [PubMed] [Google Scholar] 121.Damgaard, M

Time-lapse recording showed rotational cell movements occurring at irregular time points

The phenomenon known as ROS-induced ROS release (RIRR) describes a mechanism whereby iron overload triggers a surge of ROS in the liver [87]