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Description

These compounds have been found to block oxidative damage in isolated mitochondria and cells more effectively than untargeted antioxidant analogs due to their concentration within mitochondria

monoclonal antibodies can be generated by culturing a hybridoma cell secreting an antibody of the invention wherein, preferably, the hybridoma is generated by fusing splenocytes isolated from a mouse immunized with EphA2 or EphA4 or fragment thereof with myeloma cells and then screening the hybridomas resulting from the fusion for hybridoma clones that secrete an antibody able to bind EphA2 or EphA4

After comparing the mRNA expression of rat Ugt1 isoforms in different tissues, it was found out that rat Ugt1a isoforms are more prevalent in both liver and intestine compared to other tissues (Shelby et al., 2003)