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Acrolein inhibits cytokine gene expression by alkylating cysteine and arginine residues in the NF-kappa B1 DNA binding domain
A 2022 Phase Ib clinical trial in five human GBM patients showed that chronic CED of topotecan through an implantable and programmable subcutaneous pump was a safe therapy for recurrent GBM [84]
Muraro E, Merlo A, Martorelli D, Cangemi M, Santa SD, Dolcetti R, et al
C.DwivediM.GaniA
