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The protein carbonyl assay measures protein carbonyl derivatives formed during the oxidation of specific amino acids in proteins or introduced into proteins by a secondary reaction of nucleophilic side chains to amino acids, such as LC residues, with aldehyde products of lipid peroxidation [57]

In this way, the traditional distinction between diagnostic and selection biomarkers becomes blurred

Apoptosis can be mediated via two main pathways: the intrinsic (mitochondrial) pathway and the extrinsic (death receptor) pathway ( The mitochondrial apoptotic pathway is triggered by intracellular stimuli such as DNA damage, growth factor deprivation, and mitotic arrest