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Jankovic, J

Immunosuppressive effects of acrolein exposure were also seen in human T cells, in which acrolein directly alkylated Cys-61 and Arg-307 of NF-B1 (p50), significantly reducing binding to the promoters of IL-2, IL-10, TNF-, GMCSF, and IFN, with a notable exception being IL-8 (Lambert et al
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Future efforts should focus on: (1) Biomarker-driven stratification (e.g., NPM1 mutations confer cystine dependency, enhancing sulfasalazine-induced ferroptosis)
