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doi: 10.1093/infdis/jiaf156 167 GammagePAGaudeEVan HauteLRebelo-GuiomarPJacksonCBRorbachJet al

Underlying this metabolic reprogramming is the abnormal activation of core transcription factors such as HIF-1 and NF-B, which regulate the expression of genes related to glycolysis, amino acid catabolism, and fatty acid oxidation, respectively ( Table 1 Overview of relevant metabolites and their normal functions in COPD

Despite these advances, there are no clinically useful biomarkers that can assist the clinician in diagnosis, prognosis or assessment of treatment effects

Furthermore, reduction in bioavailable NO induces pathogenic vascular smooth muscle cell proliferation in vitro and vasoconstriction in vivo due to suppression of cGMP kinase signaling 40,41