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Gene expression studies confirm direct effects on pathways controlling hair growth, and the combination of preclinical efficacy plus clinical success in topical applications supports the rationale for injectable use

Hormonal monitoring and interventions, such as scheduling high-risk training activities during phases of lower estrogen levels, could be considered to mitigate this risk

Although the encoded proteins of these three CA related genes lack CA activity, the importance of the proteins can be demonstrated by the fact that the neurological defect in the lurcher mutant mouse is the result of a loss of CA8 gene expression

The standard 12-week escalation from 0.6mg to 2.4mg weekly balances efficacy with tolerability, producing 10-12% weight loss for most users