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We therefore performed tracer metabolomics experiments and identified an impairment in the pentose phosphate pathway in the absence of ADA2

The actions of ProBDNF and mBDNFs depend on their ability to bind to the TrkB and p75 neurotrophin receptor (p75NTR) receptors, respectively [44]

85 Moreover, the phagocytic activity of macrophages and monocytes significantly decreases during aging, leading to the accumulation of unphagocytosed debris, chronic sterile inflammation, and the exacerbation of tissue aging and damage