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As MC4R is involved in the regulation of cardiovascular function, there is concern that MC4R activation may affect those functions [24, 25]
Patients outside the UK (EU, Canada and USA) receive clear guidance on storage, administration, and follow-up care
doi: 10.1016/S0021-9258(18)55681-7 121 CooperJLMeisterA
It is therefore likely that ADA2 deficiency causes increased cell death via an indirect route that is not immediately fixed by adding functional ADA2
