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There are only few case reports where vitamin B12 deficiency was solely attributed as the cause of pyrexia.[2,3,4] The exact cause of pyrexia in megaloblastic anemia is not known but a proposed mechanism is that megaloblastic anemia leads to hyperplasia and thus increased activity within the bone marrow leading to systemic pyrexia

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Treatments that increase BDNF, whether pharmaceutical, behavioral, or peptide-based, tend to improve depressive symptoms

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For that group a hit of B12 can seem like a magical cure

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