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Conversely, loss of HDAC3 increased ARE activation activity from these sites and diminished cell cycle activity, suggesting that HDAC3 inhibitors may hold promise as a CaP treatment to restore an AR cistrome with more benign features [66]
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In most cases, the formation of these AGEs on Lys and/or Arg implies the depletion of their positive charges, thus turning these residues into neutral, zwitterionic, or even anionic residues
