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Description
Nature 399 , 7075 (1999)

While previous studies have predominantly focused on cancer, this article provides a comprehensive summary of the current understanding of the mechanism of copper ptosis, its functional role in the development of ARD, and its potential implications in pharmacology and therapeutic interventions for ARD

104 These indicate that cAMP is regulated via PDEs, and two direct downstream effectors of cAMP (PKA and Epac)

Combined or Multi-Target Approaches Due to the complex feedback within the iron-senescence-fibrosis triad, combination therapies targeting multiple pathways may be more effective than single-agent treatments
