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Controlled Drug Delivery Systems: Current Status and Future Directions. Molecules (Basel, Switzerland) 26: 5905

For some substances, it is important to think of the human or animal body as being made up of several parts, each with its own affinity for the substance, and each part with a different biological half-life (physiologically-based pharmacokinetic modelling)

summary Folic acid supplements are a practical way to boost folate levels during pregnancy, but excessive doses may increase insulin resistance and negatively affect brain development in children

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