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biocides, pesticides, plasticizers, flame retardants, industrial coatings, pharmaceuticals etc.), for which the test method is intended to predict endpoint-specific toxicity (i.e., PPAR, PPAR, adipogenesis), ii) receptor cross-talk in lipid homeostasis, and iii) be structurally relevant for the biological role of the endpoint, as shown for example with known natural or endogenous ligands, and in PPAR molecular modelling receptor ligand binding studies, as often conducted in drug discovery (5358)

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APOE4 leads to blood-brain barrier dysfunction predicting cognitive decline

J Clinic Investigat