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In oncology practice, adjuvant therapy most commonly encompasses: Adjuvant chemotherapy systemic cytotoxic agents administered after surgical resection (e.g., AC-T for breast cancer, FOLFOX for colorectal cancer) Adjuvant radiation therapy targeted ionizing radiation to the tumor bed and/or regional lymphatics after surgery Adjuvant hormonal/endocrine therapy agents such as tamoxifen, aromatase inhibitors, or leuprolide that suppress hormone-driven tumor growth after definitive treatment Adjuvant immunotherapy checkpoint inhibitors (PD-1/PD-L1 agents) or cell-based therapies administered post-resection to augment anti-tumor immune surveillance Adjuvant targeted therapy molecularly targeted agents (e.g., trastuzumab for HER2+ breast cancer) administered after surgery to block tumor-specific molecular drivers Key distinction for coders: A patient receiving adjuvant therapy has already undergone primary treatment and has no clinically evident residual disease

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