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the extensive mechanisms that regulate polyamine synthesis and trafficking often complicate efforts to modify their levels, especially locally (Miller-Fleming et al., 2015)
For example, cyanocobalamin can be risky for people with a condition called Leber's disease, as it might harm the optic nerve

On the role of calcium-permeable AMPARs in long-term potentiation and synaptic tagging in the rodent hippocampus
