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The de novo biosynthesis of sphingolipids, catalyzed by serine palmitoyltransferase, connects serine and mitochondrial alanine metabolism to membrane lipid diversity, a mechanism that could be exploited to induce tumor cell death under metabolic stress, such as in an amino acid-deprived microenvironment [126]

Front Immunol (2022) 13:838884

Notably, -hydroxybutyrate concentration less than 2.7 mmol/liter had 100% sensitivity and specificity in discriminating between surgically confirmed insulinoma patients with complete diagnostic criteria and patients with normal fast [83]

This could make it harder for the body to regulate weight